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human normal colon tissue crl1790  (ATCC)
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ATCC human normal colon tissue crl1790
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Human Normal Colon Tissue Crl1790, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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colons  (AMS Biotechnology)
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AMS Biotechnology colons
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Colons, supplied by AMS Biotechnology, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human normal colon tissue cell line ccd 18co  (ATCC)
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ATCC human normal colon tissue cell line ccd 18co
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Human Normal Colon Tissue Cell Line Ccd 18co, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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normal human colon tissue  (ATCC)
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ATCC normal human colon tissue
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Normal Human Colon Tissue, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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normal human colon tissue cells ccd 18co  (ATCC)
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ATCC normal human colon tissue cells ccd 18co
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Normal Human Colon Tissue Cells Ccd 18co, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ccd 841 con normal human colon tissue  (ATCC)
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ATCC ccd 841 con normal human colon tissue
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Ccd 841 Con Normal Human Colon Tissue, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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primary human samples consisting of matched colon adenocarcinoma tumor and normal adjacent tissue (nat)  (Tissue Solutions)
90
Tissue Solutions primary human samples consisting of matched colon adenocarcinoma tumor and normal adjacent tissue (nat)
Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells <t>(CRL1790)</t> grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)
Primary Human Samples Consisting Of Matched Colon Adenocarcinoma Tumor And Normal Adjacent Tissue (Nat), supplied by Tissue Solutions, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells (CRL1790) grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)

Journal: Journal of Experimental & Clinical Cancer Research : CR

Article Title: PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy

doi: 10.1186/s13046-025-03439-y

Figure Lengend Snippet: Ionizing radiation induces PARP gene expression in colorectal cancer cells in a microenvironment dependent manner. ( A ) Heatmap analysis depicts the expression pattern of PARP family genes in laminin-enriched 3D cell cultures of DLD1 and HT29 cells following multifractionated (5 × 2 Gy) dose ionizing radiation treatment. Unirradiated cells were used as a control. The microarray dataset originates from a previous study ( GSE75551 ). ( B ) Multifractionated irradiation experimental design. 24 h after cell plating, cells were irradiated with a single dose of X-ray (2 Gy) every 24 h for 5 days, resulting in a total dose of 10 Gy. RNA for gene expression analysis was extracted 4 h after cell irradiation. Below are schematics and representative phase-contrast images of CRC cells grown under three different plating conditions: monolayer culture (2D), three-dimensional laminin rich-extracellular matrix culture (lr-ECM 3D), and multicellular spheroid (MCS) system. Scale bars indicate 200 μm. ( C ) Expression of PARP9 , 12 , 13 , 14 genes was examined using RT-qPCR in colorectal cancer cells (DLD1, HT29) cultivated under 2D or both 3D cell culture conditions after exposure to multifractionated irradiation (5 × 2 Gy). ( D ) Similarly, the expression of PARP9 , 12 , 13 , 14 was investigated in normal colon cells (CRL1790) grown in a monolayer or lr-ECM coated 2D culture, following the same regimen of irradiation (5 × 2 Gy). Results show means with error bars representing standard deviation ( n = 3, * p < 0.05, Student’s t-test)

Article Snippet: Human normal colon tissue CRL1790 and colorectal carcinoma DLD1, HT29, HCT116 and SW48 cell lines were obtained from the American Type Culture Collection (Rockville, Maryland, USA).

Techniques: Gene Expression, Expressing, Control, Microarray, Irradiation, Quantitative RT-PCR, Cell Culture, Standard Deviation